Postpartum breast cancer risk identified

A recent study by the Pasteur Institute shows that the process of postpartum mammary repair may play a role in the development of breast cancers diagnosed after pregnancy. These cancers are often more aggressive and have a higher risk of spreading.

Timing of diagnosis matters

In France, it is estimated that 5,000 to 6,000 women are diagnosed with postpartum breast cancer each year, typically between 5 and 10 years after giving birth. These cancers are linked to a higher risk of metastasis and lower survival rates than those diagnosed at other times.

Age affects cancer risk

The risk of postpartum breast cancer increases with the mother's age at the time of pregnancy. This suggests that factors related to both age and reproductive history may influence the development of these cancers.

Postpartum mammary changes

After pregnancy and breastfeeding, the mammary gland undergoes a deep reorganization to return to its original state. This process, known as postpartum involution, resembles a healing mechanism and involves significant cellular changes.

Inflammation and cancer risk

The inflammation caused by postpartum involution temporarily increases the risk of breast cancer. This process includes the destruction of alveolar cells, immune cell recruitment, extracellular matrix restructuring, and the renewal of fatty cells, making it a delicate and critical period for the breast tissue.