For many people with disabilities, starting their own business is often the only viable option when traditional employment paths are closed due to discrimination, lack of accommodations, or other barriers. However, a recent study in France has revealed that independent workers with disabilities, known as TIH (Travailleurs Indépendants Handicapés), face a high risk of professional burnout—higher even than that of farmers, who were previously considered the most at risk. In France, around 80,000 people with disabilities work independently under the TIH status, which was established in 2016. Globally, 16% of the population, or 1.3 billion people, live with a disability, and in France, one in two people will face a disability at some point in their lives. Despite this, the unemployment rate for people with disabilities remains higher than the national average, at 11.5% compared to 7.7% in 2025. The TIH surveyed in the study are generally older, with an average age of 47.5, and more often women (64%) and highly educated (61% have a bac+5, or at least five years of higher education). Most of them work from home, and many earn very low incomes, with 43% reporting an annual turnover of less than 3,000 euros. The study examined whether this type of self-employment is "salutogenic," meaning it promotes health and well-being, or if it poses significant risks to the physical and mental health of TIH. The findings show that while disability can make the entrepreneurial path more challenging, the ability to be an entrepreneur can still contribute to well-being, especially in environments that provide adequate support. On the BMS-10 burnout scale, which ranges from 1 to 7, TIH participants had an average score of 4.22—higher than both small business managers (3.4) and farmers (3.82). Nearly half (42.1%) of the surveyed TIH showed a proven risk of burnout, and 17.5% were at severe risk. Their overall quality of life and perceived health, both physical and mental, were generally low. The study found that 65% of TIH started their businesses out of necessity, not choice, which was linked to higher burnout rates. In contrast, those who chose entrepreneurship as an opportunity reported better well-being. Common challenges of self-employment, such as managing cash flow and dealing with isolation, are compounded by disability-specific issues like income uncertainty, administrative hurdles, stigma, and discrimination. Support from family, peers, or disability-focused organizations is crucial for TIH, as traditional entrepreneurial support systems are often not adapted to their needs. Many report difficulties accessing resources or training, such as a visually impaired entrepreneur who gets lost in a business incubator, or a deaf entrepreneur who was excluded from a key training session due to the lack of an interpreter. These experiences highlight the challenges of isolation, which can worsen mental health and increase burnout risk. Yet, self-employment also offers benefits, including flexibility in work pace, a sense of accomplishment, and personal satisfaction from completing projects. For 88.9% of the participants, work was deeply tied to their sense of identity. While the study's findings are correlational and more research is needed to establish cause and effect, the message is clear: protecting the health of entrepreneurs with disabilities requires concrete actions. These include simplifying administrative processes, ensuring financial security, raising awareness about disability—especially invisible ones—and creating accessible support networks. The challenge remains: how many talented individuals will continue to suffer burnout due to a lack of an inclusive environment tailored to their needs?