Fatigue is a widespread and often severe symptom experienced by many cancer patients, and it can have a significant impact on their quality of life. While healthcare professionals may focus on other symptoms like pain, patients often report that fatigue is their main concern. This tiredness can be influenced by several factors, including the size and stage of the tumor, the presence of cancer spread (metastases), and the patient’s emotional health, such as stress or depression. These elements can interfere with sleep, worsening fatigue. Additionally, a person's social environment and their economic situation can play a major role in how they experience and cope with fatigue. Fatigue can also be an early sign that a cancer is returning or worsening, which is why it is important for doctors to assess it during every visit with an oncologist. Possible medical causes, such as anemia, nutritional deficiencies, or issues related to the endocrine or cardiovascular systems, should be investigated. Cancer treatments, such as chemotherapy, radiotherapy, and hormone therapy, can also contribute to fatigue. The severity of this fatigue often depends on the treatment’s strength and the side effects it causes. For example, women receiving hormone therapy for breast cancer may experience fatigue as a result of side effects like hot flashes and joint pain. There is currently no specific drug designed to treat cancer-related fatigue, though in some cases, psychostimulants—medications that boost alertness—may be used. Doctors often recommend non-drug strategies, such as physical activity and cognitive behavioral therapy (CBT), to help manage fatigue. Regular physical activity, especially brisk walking, has been shown to reduce fatigue by up to 30% and may also lower the risk of cancer recurrence by 25 to 30%. Guidelines suggest aiming for 150 minutes of moderate-intensity exercise per week, or 75 minutes of more intense activity, along with muscle-strengthening exercises. Cognitive behavioral therapy, delivered by a trained psychologist, can help patients manage their emotions, improve their coping strategies, and address sleep problems. Practices like yoga and meditation may also be beneficial for mental fatigue, though the scientific evidence supporting their effectiveness is not as strong as that for physical activity and CBT. In early 2021, a comprehensive care plan was introduced for cancer patients, including psychological support, adapted physical activity, and nutritional and psychological follow-up, to help address fatigue and improve overall well-being.