Nicotine, a compound found in tobacco and some nightshade vegetables like tomatoes and eggplants, is increasingly being marketed as a tool for cognitive enhancement, stress reduction, and even improved athletic performance. This trend is part of a broader movement that promotes wellness and self-optimization, often labeled as "Make America Healthy Again." Influencers, wellness communities, and even tech startups are promoting nicotine as a misunderstood substance with potential benefits, despite its long-standing association with tobacco use and addiction. These claims suggest that nicotine can improve focus, protect against cognitive decline, and even enhance mood, but they are not supported by strong scientific evidence. The resurgence of nicotine as a wellness product is being sold through noncombustible products like nicotine pouches, which deliver nicotine without the harmful effects of burning tobacco. Some products combine nicotine with caffeine or nootropics—substances that claim to improve mental function. However, while nicotine is a naturally occurring compound, the evidence that it enhances brain function or overall wellness is limited. Most studies on nicotine's effects have focused on people who already use it regularly, making it difficult to determine whether any improvements in focus or attention are due to true cognitive enhancement or simply the relief of withdrawal symptoms. Nicotine is also being linked to claims that it can improve mental health, reduce stress, and even prevent diseases like Alzheimer’s or Parkinson’s. These assertions are based on some preliminary research on animal models and laboratory studies, but there is no solid evidence that nicotine prevents or treats these conditions in humans. In fact, long-term nicotine use may impair the body's natural ability to manage stress and could increase the risk of mental health issues. Quitting nicotine has been consistently associated with improvements in mood, anxiety, and overall well-being, suggesting that its benefits for mental health are likely overstated. The U.S. Food and Drug Administration has approved nicotine replacement therapies such as patches, gum, and lozenges to help people quit smoking by reducing withdrawal symptoms. These products are effective when used as part of a structured plan to stop tobacco use. However, using nicotine in other ways—such as for cognitive enhancement or to improve performance—can lead to dependence and may not provide the health benefits that are often claimed. While nicotine may offer short-term effects like increased alertness or temporary stress relief, its long-term risks and lack of proven benefits for wellness or longevity mean that its use should be approached with caution.