Long Covid, a condition affecting millions of people worldwide, refers to a range of symptoms that persist for weeks or even months after a person has recovered from a SARS-CoV-2 infection. These symptoms can include fatigue, shortness of breath, brain fog, and muscle pain, and their causes are still not fully understood. Recent studies have suggested that two potential mechanisms might be involved in the development of long Covid. One possible mechanism involves abnormalities in the formation of new blood vessels, a process known as angiogenesis. In some cases, this process may be disrupted, leading to reduced blood flow to certain parts of the body. Another mechanism involves inflammation of the inner walls of blood vessels, which can impair their function and contribute to ongoing health issues. Researchers have identified a molecule that plays a key role in blood vessel formation and are exploring whether targeting this molecule could help alleviate some of the symptoms associated with long Covid. If successful, this approach could offer new treatment options for those suffering from prolonged effects of the virus. A clinical trial is currently being planned to test this hypothesis. The trial will involve participants who have been diagnosed with long Covid and will assess whether targeting the molecule leads to improvements in their symptoms. If the results are promising, it could mark a significant step forward in understanding and treating this complex condition.