Seren Lockwood has been ruled out of Wales' upcoming WXV Global Series match against the USA after failing a head injury assessment (HIA). Lockwood was substituted during the first half of Wales' recent 8-try win over South Africa and is now undergoing World Rugby's return to play protocols, which are designed to ensure player safety following head injuries. Her absence means Lleucu George will move to the 10 position, while Keira Bevan will return to her usual role at nine. Wales head coach Sean Lynn expressed concern over Lockwood's injury but praised the HIA process, stating, "It's always sad to see an individual coming off, but the HIA is great to have on board, we're looking after her. She's not going to be available this weekend, but I'm super excited to see the half-back combination that we've got this week." Carys Cox's recovery from summer knee surgery has given Lynn more flexibility in the backline, as Cox is capable of playing both centre and wing. "Carys has been superb in rehab, she feels fitter, faster and stronger," said Lynn. "She always brings a smile, she's always confident and I love her athleticism. She will always beat that first defender and the way we are playing now, she's going to get some ball in hand." Her return adds depth to Wales' squad and offers a positive outlook as the team prepares for the upcoming match. Nel Metcalfe will also miss Saturday's game against the USA, as she continues her rehabilitation from injury and is not expected to be available until next month's two-Test tour of Japan. "Nel is progressing really well with her rehab, we saw her today in some rugby elements, so fingers crossed we will be seeing her in Japan," Lynn said. Her progress has been encouraging, and the team is hopeful for her return in the near future. The match between Wales and the USA is scheduled for Saturday, 26 September at 15:00 BST at Cardiff Arms Park. It will be broadcast live on BBC One, iPlayer, and the BBC Sport website and app, with live text coverage also available. Fans and viewers can look forward to a high-stakes encounter as Wales aims to secure a strong result in the WXV Global Series.