A plant-based diet can alter liver metabolism in mice, affecting glucose production and physical activity, according to a study in Molecular Metabolism.
Study on plant-based diets in mice
A study by researchers at the University of Geneva found that switching to a strictly plant-based diet can alter liver metabolism in mice within just a few days. The findings were published in October 2026 in Molecular Metabolism.Impact on glucose and ammonia
The study compared two groups of mice: one fed a diet combining animal and plant proteins, and the other on a strictly plant-based diet. Within two days, the mice on the plant-based diet produced less glucose and had more difficulty eliminating ammonia.Decreased physical activity
This disruption led to a significant decrease in physical activity among the mice that switched to the plant-based diet. The mice showed reduced motivation to move, likely due to the changes in their metabolism.Reversible effects
However, the effects were found to be reversible. When animal proteins were reintroduced into the diet, the liver resumed its normal function within one or two days. This suggests that the changes were not permanent.Role of branched amino acids
The research highlights the role of branched amino acids, which are more abundant in animal proteins, in maintaining liver function and blood sugar levels during fasting. These amino acids appear to be crucial for the liver's normal operations.Potential influence on behavior
The study suggests that the shift in protein sources affects the entire body, potentially influencing motivation for physical activity. This indicates that dietary changes may have broader impacts beyond metabolism.
