Study identifies fear-inducing neurons
A team from Northwestern University discovered a specific group of neurons that cause uncontrollable fear reactions in mice when exposed to cannabinoids. This finding, published in Nature Communications in October 2026, helps explain why some people experience sudden anxiety after using cannabis.Cannabinoid effect linked to anxiety
The study found that a synthetic cannabinoid, when given to mice before the smell of fox urine, significantly increased their fear response. Treated mice froze and avoided the source, while those given a placebo approached it without fear.Inhibitory neurons play key role
Researchers identified a small group of somatostatin neurons in the central amygdala as the cause. These inhibitory cells normally act as a brake on fear responses, but under the influence of cannabinoids, their function is disrupted.Shift in threat response behavior
Normally, mice approach a potential threat to assess it. However, under the influence of cannabinoids, this behavior changes to immediate and intense fear, even when the actual risk is low.Techniques reveal neural activity
To observe the process, researchers used a tiny microscope implanted in the mice's brains. Combined with brain slice analysis, the study confirmed the mechanism behind the altered fear responses.
