A new study finds that higher physical activity is linked to less severe depression symptoms, even for those with high genetic risk.
Study links physical activity to less severe depression symptoms
A new study suggests that higher levels of physical activity are associated with less severe symptoms in people with depression, including those who have a high genetic risk for the condition. The findings were published in Nature Mental Health and examined data from over 23,000 individuals in the United States.Research used Fitbit data and genetic information
The study used data from the All of Us research program, which includes participants aged 18 to 92 years, with an average age of around 56 years. Physical activity levels were estimated using data from Fitbit devices, avoiding the potential inaccuracies of self-reported measures.Genetic risk assessed through genome sequencing
Researchers calculated a polygenic risk score for depression using whole-genome sequencing data. This score reflects the cumulative effect of many genetic variations that may contribute to the condition. Depression diagnoses were confirmed through a combination of electronic medical records and self-reported information.Higher activity linked to milder symptoms in high-risk individuals
Among participants with major depressive disorder and a higher genetic risk, those who engaged in more physical activity experienced less severe symptoms. However, the study does not establish that exercise directly treats depression or reduces genetic risk. The findings highlight a potential association rather than a causal relationship.
