According to Santé publique France, more than 23% of the French population has elevated levels of "bad cholesterol," known as LDL. Doctors caution that when these levels exceed a certain threshold, it can increase the risk of heart attack or stroke. A special dossier on pages 26 to 38 provides advice on ways to reduce bad cholesterol levels and improve overall cardiovascular health. Age-related weight gain is a common and natural process supported by statistical data. While it is a normal part of aging, it is not an unavoidable outcome. Lifestyle changes, such as regular physical activity and dietary adjustments, can help individuals maintain a healthier weight. Specialists in endocrinology and therapeutic education offer guidance on making these necessary changes on page 75. A new approach to longevity emphasizes preserving skin health and function rather than simply trying to eliminate visible signs of aging. Inspired by the principles of longevity medicine, a new line of skincare products focuses on prevention, repair, and enhancing the skin's resilience. Experts in dermatology and molecular biology review the most effective products on page 91. Other topics featured in the publication include discussions on the fear of becoming obsolete due to artificial intelligence on page 16; an investigation into occupational diseases on page 18; an interview with Agès Ledig on page 24; advice for managing autumn fatigue on page 38; an exploration of lymphatic walking on page 58; testimonies about living with eco-anxiety on page 68; recipes for an anti-stress diet on page 82; an examination of laser treatment for acne on page 100; a program for maintaining a young brain on page 116; and the secrets of Italian longevity known as the Trentin on page 120.