Researchers in Tokyo have inserted the gene for the Dsup protein, derived from a Japanese tardigrade, into human cells cultivated in the laboratory. When exposed to X-rays, these modified cells showed 40% fewer DNA breaks than classical human cells subjected to the same doses. This discovery could, in the long term, better protect healthy tissues during radiotherapy and reduce the cellular damage suffered by astronauts during long stays in space.
The tardigrade, also known as a water bear, is a microscopic organism that can survive in extreme conditions, including exposure to the vacuum of space and temperatures close to absolute zero. It can enter an extreme state of dormancy called cryptobiosis, reducing its metabolism to almost zero to survive periods of drought, freezing, or intense radiation. What intrigues scientists most is its ability to withstand doses of ionizing radiation hundreds of times higher than those that would be lethal for a human being.
The secret of the tardigrade lies in a protein called Dsup, an acronym for the English "Damage suppressor." This molecule acts like a kind of molecular shield that wraps around the DNA, forming a protective physical layer. When ionizing radiation passes through a cell, it generates free radicals capable of cutting the DNA chains, causing mutations or cell death. The Dsup protein, by tightly attaching to the DNA, limits the access of these destructive agents and significantly reduces the breaks.
Researchers have introduced the gene coding for the Dsup protein directly into human cells in culture, using standard molecular biology techniques. The results surprised even the researchers themselves. The cells carrying the Dsup gene showed a 40% reduction in DNA breaks compared to classical human cells exposed to the same radiation doses.
The potential applications of this discovery first touch the medical field. Radiotherapy, a treatment frequently used against certain cancers, damages not only the tumor cells but also the surrounding healthy tissues. If one day it were possible to selectively protect healthy cells using a mechanism inspired by Dsup, it would potentially allow increasing therapeutic doses while limiting side effects, a balance that oncologists have been seeking for decades.
The other sector directly concerned is space exploration. Astronauts who venture beyond low Earth orbit, especially during missions to the Moon or Mars, are exposed to much higher levels of cosmic radiation than we experience on Earth, where the atmosphere and magnetic field naturally protect us. A genetic protection inspired by the tardigrade could, in the long term, help limit the cellular damage associated with these long stays in space.
This advancement illustrates an approach still relatively recent in biology: rather than trying to "repair" human weaknesses through purely chemical or technological means, some researchers now choose to look directly into nature for solutions already tested by millions of years of evolution.
Tardigrade Protein Shows Potential to Protect Human Cells from Radiation Damage
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