Oklahoma State made history on Saturday by defeating No. 6 Oregon 39-31 in a stunning upset, marking the first major shock of the college football season. The Cowboys were heavily favored to lose, entering the game as 23.5-point underdogs after a tough loss to Tulsa the previous week and a 69-3 defeat to Oregon last season. Oklahoma State had also struggled on the field, losing 21 straight games against Football Bowl Subdivision (FBS) teams and 12 in a row overall across two seasons, with their only win coming against an FCS team, Tennessee Martin, in the season opener. Despite the daunting odds, Oklahoma State's defense held Oregon's high-powered offense in check and outgained them in total yards, 554 to 448. Quarterback Drew Mestemaker led the charge, throwing for 317 yards and two touchdowns, and adding a 10-yard touchdown run that gave Oklahoma State a 36-31 lead with 4.5 minutes remaining in the fourth quarter. Mestemaker described the victory as "the best moment of my life." Head coach Eric Morris, who earned his first win at Oklahoma State, said the victory was "unbelievable" and joked that he might "think about retiring tonight" after the emotional win. The victory set the stage for a highly anticipated matchup between No. 1 Ohio State and No. 4 Texas later that Saturday night, which many expect to be one of the top games of the season. The rivalry, which is only 21 years old, has Ohio State holding a 3-2 edge after their 14-7 win in Columbus last year. Both teams have strong rosters with standout players, including quarterbacks Julian Sayin and Arch Manning, receivers Jeremiah Smith and Cam Coleman, and running backs Bo Jackson and Hollywood Smothers. The outcome could have major implications for the College Football Playoff bracket. Texas is looking to secure its first win over a No. 1 team since 2008 and gain bragging rights for the Big Ten or the Southeastern Conference, which were undefeated through Week 1. Meanwhile, Mississippi quarterback Trinidad Chambliss is expected to have another productive day as the Rebels face Charlotte on Saturday. Chambliss threw for 336 yards and three touchdowns in the season-opening win over Louisville. However, he may not play a full game since Mississippi is a 45-point favorite, indicating the game might be used as a tune-up for the rest of the season.