A headache, fever, or muscle pain after physical activity often leads people to reach for paracetamol, a common over-the-counter drug used to relieve mild to moderate pain and reduce fever. However, recent comments by toxicologist David Healy have raised concerns about its long-term safety. He suggested that if paracetamol were to be submitted to health authorities today, it might not be approved, due to potential risks associated with its use. Recent studies have highlighted possible health risks linked to the prolonged use of paracetamol. For example, research in the UK found that taking more than 15 tablets per week could increase the risk of cardiovascular issues by up to 68%. Another study suggested that consuming more than 500 grams of paracetamol over a lifetime could double the risk of kidney problems. A 2024 study also noted a 28% higher risk of liver cancer among those who use the drug regularly. In France, where more than 200 medications contain paracetamol, the risk of unintentional overdose is a concern, especially when combined with other medications. The recommended daily limit is 3 grams, with a 4-hour gap between doses, and treatment should not exceed 3 to 5 days without consulting a healthcare professional. An overdose can lead to severe liver damage, which is the leading cause of drug-induced liver transplants in the country. While the increased risks identified in the studies are described as moderate, researchers caution that the lack of high-quality studies makes it difficult to fully interpret these findings. Paracetamol, sold under names like Doliprane, Dafalgan, or Efferalgan, is widely used without a prescription. Healy’s warnings stand out because of how commonly the drug is used, often without much consideration of its potential risks. The current advice is to carefully check the composition of medications to avoid accidental paracetamol use and to consult a pharmacist if unsure. While paracetamol is generally seen as safer than non-steroidal anti-inflammatory drugs or opioids, recent alerts emphasize the need for caution with prolonged use and high doses, not occasional use. The overall message is to use the drug carefully, recognizing that no medication is entirely risk-free when used over a long period without medical guidance.