Paracetamol, a medication commonly found in households and available without a prescription, is the leading cause of medication-induced liver transplantation in France. While it is often perceived as harmless, the margin of safety for its use is narrower than many people realize. Medical professionals note that exceeding 4 grams of paracetamol per 24 hours, with a maximum of 1 gram per dose spaced 4 to 6 hours apart, can lead to serious health risks. The combination of paracetamol with alcohol is particularly dangerous, as both substances affect the liver, increasing the risk of toxicity even at therapeutic doses. The French National Agency for Medicines Safety (ANSM) has mandated a direct warning message on the packaging of medications containing paracetamol alone, reminding users that exceeding the dose can destroy the liver. The MSD Manual sets the threshold for acute poisoning around 150 mg per kilogram, or approximately 7.5 to 10 grams for an adult over 24 hours. This figure may seem distant but can be approached dangerously in cases of accumulation or pre-existing liver fragility. People under 50 kilograms, the elderly, those with liver or kidney insufficiency, and chronic alcohol consumers are among the profiles that need closer monitoring. Specialists advise waiting several hours after significant alcohol consumption before taking paracetamol to avoid overburdening the liver. To prevent overdoses, it is recommended to count doses precisely, respect intervals of at least 4 to 6 hours between each dose, check the composition of other medications, especially those for colds or flu, avoid alcohol during paracetamol treatment, especially if it lasts several days, and consult a pharmacist before combining several treatments, even those available over the counter. In case of doubt about a possible overdose, it is better to immediately contact a poison control center or go to the emergency room, as liver damage can become irreversible if not addressed in time.