Hayden Panettiere, a 36-year-old actress known for her roles in television and film, has been confirmed to have died from the toxic effects of multiple substances, according to the Greenville County Coroner's Office. The coroner's official report listed fentanyl, 4-ANPP, Alprazolam, Methocarbamol, and Quetiapine as contributing factors. The manner of death was classified as an accident, with no signs of trauma or foul play detected. Panettiere was found unresponsive in a South Carolina apartment complex on August 16 and was pronounced dead after emergency responders arrived following a report of cardiac arrest. The Greenville Police Department noted no evidence of criminal activity during their initial investigation, and the Drug Enforcement Administration (DEA) was also involved in the inquiry. Panettiere’s on-again, off-again boyfriend at the time, Brian Hickerson, was present at the scene and showed authorities what was described in a police report as a "bag of medication" he said she was taking. Hickerson had previously pleaded no contest to a charge of injuring a spouse or girlfriend in 2019, receiving four years of probation. In 2020, Panettiere had sought a restraining order against Hickerson, though the outcome of that request is not clear. In her recently released memoir, This Is Me: A Reckoning, Panettiere spoke openly about her battles with addiction and postpartum depression. She had a daughter with Ukrainian boxer Wladimir Klitschko in 2014 and granted him full custody of their child in 2018 while she was dealing with these personal challenges. Panettiere began her career as a child model and actress, gaining wider recognition with her role on the NBC series Heroes. She later received two Golden Globe nominations for her performance in the show Nashville and appeared in the Scream film franchise. Emergency responders attempted to resuscitate Panettiere upon arrival, using advanced cardiac life support measures, but their efforts were unsuccessful. According to a police report, both Hickerson and his brother Zack were present when emergency services arrived. The coroner’s report confirmed no signs of criminal activity, and Panettiere’s family released a statement on August 17 announcing her death, though they did not specify the cause at that time. She was found unconscious and in cardiac arrest when emergency services arrived.