At the closing of the 5th Mayotte Health Conference, Moncef Mouhoudhoire, director of the Nariké M’sada association, urged attendees to continue the discussions beyond the event, aiming to turn the conference's insights into real-world collaborations that benefit the most vulnerable people. The conference, held in Mayotte, brought together health professionals, researchers, and organizations from several regions, including Mauritius, the Comoros, Reunion, French Guiana, and mainland France. The event focused on the theme "At the Edges of Care, Rights, and Journeys," highlighting the difficulties people in Mayotte face in accessing healthcare, rights, and preventive services. Mouhoudhoire emphasized the need to keep the dialogue going after the conference ended. He stressed the importance of identifying and addressing issues that are often overlooked, particularly for those who are difficult to reach through existing systems. He called for creating solutions in partnership with the people affected and neighboring regions, ensuring that rights are not only recognized but also accessible in practice. According to Mouhoudhoire, the challenges discussed at the conference are not limited to migrants but also affect the broader Mahorais society, especially in a context of deep social and economic inequality. He explained that the "edges" referenced in the conference's theme include social, economic, and geographical factors. Statistics show that in 2017, 77% of Mayotte's population lived below the national poverty threshold. By 2022, prices in Mayotte were, on average, 10% higher than in mainland France, with even greater differences for certain food items. These conditions directly influence access to healthcare and the ability of residents to engage in sustainable prevention and care efforts. The conference also addressed the issue of drug use in Mayotte, revealing the limitations of current methods for understanding and monitoring such challenges. While drug use exists in the region, it remains poorly understood due to a lack of continuous and structured data. Wastewater analysis, a method that can provide objective insights into drug consumption at the population level, is not widely used in Mayotte. Available information suggests that the term "chemical," used locally to describe synthetic drugs, is not limited to isolated or marginalized individuals. Some users are integrated into society, living in stable housing, in a context where drug distribution and consumption patterns are rapidly evolving, particularly through maritime routes. Researchers have identified several synthetic cannabinoids in products collected in Mayotte through the Chasse-Marée protocol, an ongoing research initiative. In response to these developments, addiction professionals are advocating for improved local analytical capabilities, including the potential creation of a mobile laboratory. The goal is to move away from sporadic observations and instead establish regular monitoring of drug use. Better identification of the substances circulating in the region could lead to more effective prevention strategies, risk reduction efforts, and care for those affected. The French Observatory for Drugs and Addiction (OFDT) has noted that the situation regarding drugs and addiction in Mayotte remains under-researched and poorly documented.